I'd love to see a e-sport league where the teams are AI human hybrids (Centaur teams). We know that AI human hybrid teams are great at chess [1],
and I'd love to see rts games played by 'Centaur' teams. In the same way the innovations made in F1 often trickle down to consumer cars, can you imagine the advances that could be made in human-machine interactions in the crucible of a real-time Centaur gaming league?
I'd rather that the coding was something that was left to the player or to the third party market. Right now programming games are kind of boring, more like a way of prettying up homework than anything else. A really fun game where programming could give you a competitive edge would be something to see.
The closest thing I can think of is add-ons for MMOs, but there the game developers specifically try to prevent add-ons that are too performance enhancing instead of making the coding an integral part of the game.
[1] http://bloomreach.com/2014/12/centaur-chess-brings-best-huma...