It's not really clear to me what you mean with "scale" here. Are you referring to the scale of a program, i.e. size in LoC and/or complexity of components, or to the scale of a team of developers, i.e. the number of persons working on a given codebase?
Scale in performance, since dynamically typed languages have fundamental hurdles that will always make programs slower than when written in a statically typed language.
And scale in code base and developer strain. The fact that it's mathematically impossible to reliably refactor code automatically if the types are absent encourage spaghetti code bases that developers are afraid to modify because they can never be sure they're not breaking anything.
Such hesitations never happen in statically typed languages.
