As someone who lives in the middle of the ocean with ~70ms to the nearest major data center, you get used to it.

You’re at a disadvantage to people with low ping, but it’s certainly not unplayable.

It really depends on the game. I would say 70-100ms is the upper acceptable limit for FPSs (though some like CS:GO or Valorant require even lower), but even like 150-250ms is okay for casual MOBA play.